Among the vast array of methods available for biochemical analysis,
chromatography occupies a venerable station. Few analytical methods
have had such vital impact on the development of clinical chemistry
and toxicology. In this book, the editors have assembled a
cross-section of contemporary applications of chromatographic
methods used in clinical chemistry and toxicology. The opening
chapter focuses on QA and QC, emphasizing the importance of
validating analytical methods that are used for clinical and
forensic purposes Chapters 2 to 6 discuss applications of
chromatographic methods in the detection of anabolic steroids in
urine; the detection and measurement of popular nutritional
supplements; measurement of L-dopa and L-tyrosine as markers of
malignant melanoma; capillary zone electrophoresis combined with LC
and MS to measure proteins in plasma; use of HPLC to detect
abnormally glycosolated transferrin; and the measurement of
catecholamines, which are specific markers of neuroendocrine
tumors. Chapters 7 to 11 focus on toxicology applications,
including a description of the analysis of alcohols and inhalants;
LC methods for measuring organophosphate pesticides, and the
detection and identification of neurotoxins used as biochemical
weapons; and a GC/MS method for measuring g-hydroxybutyrate and
analogues. The final two chapters present chromatographic methods
adapted to the analysis of heavy metals in biological specimens: LC
and ICP to measure arsenic, mercury, selenium, and platinum in a
variety of biological matrices; and measurement of heavy metals by
generating volatile chelates that are separated by GC and detected
by MS.
The twelve applications described in this bookillustrate the
versatility of chromatographic methods, and the range of
applications to clinical chemistry and toxicology available with
this powerful analytical technique. The book provides an overview
of useful methods, while emphasizing the contributions that
chromatography continues to make in clinical laboratory
medicine.
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