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Therapeutic Peptides and Proteins - Formulation, Processing, and Delivery Systems, Third Edition (Hardcover, 3rd edition)
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Therapeutic Peptides and Proteins - Formulation, Processing, and Delivery Systems, Third Edition (Hardcover, 3rd edition)
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There are more than 500 biopharmaceuticals on the market, including
more than 200 therapeutic proteins, making biologics the fastest
growing sector in the biopharmaceutical market. These products
include more than 40 monoclonal antibodies, for indications ranging
from treatment or mitigation of various types of cancer to
rheumatoid arthritis. The clinical application of these therapeutic
peptides and proteins is limited by several problems, such as lack
of physical and chemical stability or the lack of desirable
attributes for adequate absorption or distribution. Thus, as these
therapeutic peptides and proteins are made available, it will be
essential to formulate these drugs into safe, stable, and
efficacious delivery systems. The pharmaceutical scientist involved
in this effort needs to call upon the knowledge of several
disciplines, such as pharmaceutics, medicinal chemistry,
biochemistry, microbiology, and chemical engineering and needs to
keep abreast with the latest research in the published literature.
Therapeutic Peptides and Proteins: Formulation, Processing, and
Delivery Systems, Third Edition provides a comprehensive overview
of the field for scientists in industry and academia and for
students, while also providing practical information on the
challenges facing the formulation and delivery aspects of these
unique macromolecules. In particular, the book: Explains how
recombinant DNA techniques now allow us to produce therapeutic
proteins in a commercially viable form Discusses the physical and
chemical pathways of peptide and protein degradation Includes a
detailed discussion of protein formulation and lyophilization
Overviews the pharmacokinetic aspects of therapeutic peptides and
proteins and discusses controlled delivery systems for parenteral
administration, including microsphere formulations Discusses
research progress on oral, transdermal, mucosal, and topical
delivery systems discusses transdermal and topical delivery
General
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