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Books > Professional & Technical > Biochemical engineering > Biotechnology
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Bioseparations of Proteins, Volume 1 - Unfolding/Folding and Validations (Hardcover)
Loot Price: R4,988
Discovery Miles 49 880
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Bioseparations of Proteins, Volume 1 - Unfolding/Folding and Validations (Hardcover)
Series: Separation Science and Technology
Expected to ship within 12 - 17 working days
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This book covers the fundamentals of protein inactivation during
bioseparation and the effect on protein processing. Bioseparation
of Proteins is unique because it provides a background of the
bioseparation processes, and it is the first book available to
emphasize the influence of the different bioseparation processes on
protein inactivation.
Bioseparation of Proteins covers the extent, mechanisms of, and
control of protein inactivation during these processes along with
the subsequent and essential validation of these processes. The
book focuses on the avoidance of protein (biologicalproduct)
inactivation at each step in a bioprocess. It compares protein
inactivation exhibited during the different bioseparation processes
by different workers and provides a valuable framework for workers
in different areas interested in bioseparations.
Topics include separation and detection methods; estimates of
protein inactivation and an analysis of this problem for different
separation processes; strategies for avoiding inactivation; the
molecular basis of surface activity and protein adsorption, process
monitoring, and product validation techniques; and the economics of
various bioseparation processes and quality control procedures.
Key Features
* Protein inactivation and other aspects of biological stability
are critical to an effective bioseparation process; This book is a
detailed and critical review of the available literature in an area
that is essential to the effectiveness, validation, and economics
of bioseparation processes for drugs and other biological products;
Conveniently assembled under one cover, the survey of the
literature and resulting perspective will greatly assist engineers
and chemists in designingand improving their own processes; Key
features of the text include:
* detailed data on biological stability under various bioseparation
conditions
* extensive case studies from the literature on separation
processes, validation, and economics
* simplified analysis of protein refolding and inactivation
mechanisms
* consideration of adsorption theories and the effect of
heterogeneity
* coverage of both classical and novel bioseparation techniques,
including chromatographic procedures
General
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