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Discovering Retroviruses - Beacons in the Biosphere (Hardcover) Loot Price: R403
Discovery Miles 4 030
You Save: R122 (23%)
Discovering Retroviruses - Beacons in the Biosphere (Hardcover): Anna Marie Skalka

Discovering Retroviruses - Beacons in the Biosphere (Hardcover)

Anna Marie Skalka

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List price R525 Loot Price R403 Discovery Miles 4 030 You Save R122 (23%)

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Approximately eight percent of our DNA contains retroviral sequences that are millions of years old. Through engaging stories of scientific discovery, Anna Marie Skalka explains our evolving knowledge of these ancient denizens of the biosphere and how this understanding has significantly advanced research in genetic engineering, gene delivery systems, and precision medicine. Discovering Retroviruses begins with the pioneer scientists who first encountered these RNA-containing viruses and solved the mystery of their reproduction. Like other viruses, retroviruses invade the cells of a host organism to reproduce. What makes them "retro" is a unique process of genetic information transfer. Instead of transcribing DNA into RNA as all living cells do, they transcribe their RNA into DNA. This viral DNA is then spliced into the host's genome, where the cell's synthetic machinery is co-opted to make new virus particles. The 100,000 pieces of retroviral DNA in the human genome are remnants from multiple invasions of our ancestors' "germline" cells-the cells that allow a host organism to reproduce. Most of these bits of retroviral DNA are degenerated fossils, but some have been exploited during evolution, with profound effects on our physiology. Some present-day circulating retroviruses cause cancers in humans and other animals. Others, like HIV, cause severe immunodeficiencies. But retroviruses also hold clues to innovative approaches that can prevent and treat these diseases. In laboratories around the world, retroviruses continue to shed light on future possibilities that are anything but "retro."

General

Imprint: Harvard University Press
Country of origin: United States
Release date: October 2018
Authors: Anna Marie Skalka
Dimensions: 235 x 156 x 21mm (L x W x T)
Format: Hardcover
Pages: 192
ISBN-13: 978-0-674-97170-7
Languages: English
Subtitles: English
Categories: Books > Medicine > Clinical & internal medicine
Books > Science & Mathematics > Biology, life sciences
Books > Medicine > Clinical & internal medicine > Diseases & disorders
Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues
Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Evolution
Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)
Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > Virology
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases > HIV / AIDS
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > General
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LSN: 0-674-97170-1
Barcode: 9780674971707

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