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Books > Medicine > Other branches of medicine > Pathology > Medical microbiology & virology
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Antibiotic Resistance (Paperback, 2012 ed.)
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Antibiotic Resistance (Paperback, 2012 ed.)
Series: Handbook of Experimental Pharmacology, 211
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This book describes antibiotic resistance amongst pathogenic
bacteria. It starts with an overview of the erosion of the efficacy
of antibiotics by resistance and the decrease in the rate of
replacement of redundant compounds. The origins of antibiotic
resistance are then described. It is proposed that there is a large
bacterial resistome which is a collection of all resistance genes
and their precursors in both pathogenic and non-pathogenic
bacteria. Ongoing resistance surveillance programs are also
discussed, together with the perspective of a clinical
microbiologist. The book then turns to specific themes such as the
most serious area of resistance in pathogens, namely in
Gram-negative organisms. The role of combinations of antibiotics in
combating resistance emergence is discussed, particularly in the
tuberculosis field, and then the importance of non-multiplying and
persistent bacteria which are phenotypically resistant to
antibiotics and prolong the duration of therapy of antibiotics
which leads to poor compliance and resistance emergence. The role
of anti-microbial compounds in textiles is covered, with its
potential to exacerbate the spread of resistance. Then, efflux
pumps are discussed. The final chapter describes the compounds
which are in late stage clinical development, illustrating the
paucity of the antibiotic pipeline, especially for Gram-negative
bacteria.
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