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Cooperativity and Regulation in Biochemical Processes (Paperback, Softcover reprint of hardcover 1st ed. 2001)
Loot Price: R3,149
Discovery Miles 31 490
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Cooperativity and Regulation in Biochemical Processes (Paperback, Softcover reprint of hardcover 1st ed. 2001)
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This book evolved from a graduate course on applications of
statistical thermody- namics to biochemical systems. Most of the
published papers and books on this subject used in the course were
written by experimentalists who adopted the phenomenological
approach to describe and interpret their results. Two outstanding
papers that impressed me deeply were the c1assical papers by Monod,
Changeux, and Jacob (1963) and Monod, Wyman, and Changeux (1965),
where the allosteric model for regulatory enzymes was introduced.
Reading through them I feIt as if they were revealing one of the
c1everest and most intricate tricks of nature to regulate
biochemical processes. In 1985 I was glad to see T. L. HilI's
volume entitled Cooperativity Theory in Biochemistry, Steady State
and Equilibrium Systems. This was the fIrst book to systematically
develop the molecular or statistical mechanical approach to binding
systems. HilI demonstrated how and why the molecular approach is so
advanta- geous relative to the prevalent phenomenological approach
of that time. On page 58 he wrote the following (my italics): The
naturalness of Gibbs' grand partition function for binding problems
in biology is evidenced by the rediscovery of what is essentially
the grand partition function for this particular type of problem by
various physical biochentists, including E. Q. Adams, G.
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