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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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Physics at the Biomolecular Interface - Fundamentals for Molecular Targeted Therapy (Hardcover, 1st ed. 2016)
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Physics at the Biomolecular Interface - Fundamentals for Molecular Targeted Therapy (Hardcover, 1st ed. 2016)
Series: Soft and Biological Matter
Expected to ship within 12 - 19 working days
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This book focuses primarily on the role of interfacial forces in
understanding biological phenomena at the molecular scale. By
providing a suitable statistical mechanical apparatus to handle the
biomolecular interface, the book becomes uniquely positioned to
address core problems in molecular biophysics. It highlights the
importance of interfacial tension in delineating a solution to the
protein folding problem, in unravelling the physico-chemical basis
of enzyme catalysis and protein associations, and in rationally
designing molecular targeted therapies. Thus grounded in
fundamental science, the book develops a powerful technological
platform for drug discovery, while it is set to inspire scientists
at any level in their careers determined to address the major
challenges in molecular biophysics. The acknowledgment of how
exquisitely the structure and dynamics of proteins and their
aqueous environment are related attests to the overdue recognition
that biomolecular phenomena cannot be effectively understood
without dealing with interfacial behaviour. There is an urge to
grasp how biologically relevant behaviour is shaped by the
structuring of biomolecular interfaces and how interfacial tension
affects the molecular events that take place in the cell. This book
squarely addresses these needs from a physicist perspective. The
book may serve as a monograph for practitioners and, alternatively,
as an advanced textbook. Fruitful reading requires a background in
physical chemistry and some basics in biophysics. The selected
problems at the end of the chapters and the progression in
conceptual difficulty make it a suitable textbook for a graduate
level course or an elective course for seniors majoring in
chemistry, physics, biomedical engineering or related disciplines.
General
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