This book, for the first time, comprehensively assembles and
analyzes a large body of information on the role of the fundamental
mechanism of the protein biosynthesis pathway, translation, in
cancer biology. It systematically explores the function of the
translation machinery and its regulation, including cell signaling,
in the development, maintenance and progression of human cancer.
The work presented here unveils the tremendous potential and
applications of this vast and exciting branch of genetic,
biochemical and molecular science in cancer medicine and drug
development.
Chapters contributed by experts in the field take the reader on
a journey that starts with a dissection of the translation
machinery and its regulation in norm and cancer. Later chapters
characterize etiological and pathogenetic roles that translation
plays in specific cancer types. Various aspects of diagnostic,
prognostic and therapeutic significance of the translation
machinery and its control in cancer are discussed. Readers will
discover the importance of the process of translation and its
regulatory mechanisms in physiology and cancer biology.
The chapters and the numerous illustrations included here were
contributed by expert scientists and clinicians from renowned
academic and clinical establishments in Canada, the United States
of America, the United Kingdom, Italy, France, Belgium, Spain,
Germany and Australia.
The book conveys information and knowledge that may interest a
broad range of students and scholars ranging from basic scientists
to clinicians and drug developers seeking to better understand the
protein synthesis and its aberrations in cancer biology and cancer
medicine.
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