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Autophagy in Stem Cell Maintenance and Differentiation (Hardcover, 1st ed. 2023)
Loot Price: R4,979
Discovery Miles 49 790
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Autophagy in Stem Cell Maintenance and Differentiation (Hardcover, 1st ed. 2023)
Series: Stem Cell Biology and Regenerative Medicine, 73
Expected to ship within 10 - 15 working days
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This book covers a wide range of topics that illustrate the various
functions of autophagy in stem cells and offers insights on the
mechanisms by which autophagy can regulate stem-cell self-renewal
and facilitate specific differentiation programs. Stem cells are
unique cells present in most multicellular animals and are
essential for their survival. They have two unique properties: the
ability to self-renew and the ability to differentiate into one or
more cell types. These characteristics of stem cells have found
immense therapeutic potential in regenerative medicine. Autophagy
is a crucial membrane trafficking pathway that is essential for
maintaining cellular homeostasis that involves sequestration of
non-functional proteins, protein aggregates and damaged organelles
in double-membraned vesicles called autophagosomes, which are
subsequently targeted to the lysosome for degradation. The primary
aim of this book is to provide knowledge of recent developments in
our understanding of the role of autophagy in stem cells, including
germline stem cells. Autophagy is considered a promising target for
many diseases. Significant efforts are being developed to identify
specific modulators of autophagy, which will aid in designing
combinatorial therapeutic strategies that will allow significant
improvements in regenerative medicine.
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