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Development of a Fully Integrated "Sample-In-Answer-Out" System for Automatic Genetic Analysis (Hardcover, 1st ed. 2018)
Loot Price: R3,272
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Development of a Fully Integrated "Sample-In-Answer-Out" System for Automatic Genetic Analysis (Hardcover, 1st ed. 2018)
Series: Springer Theses
Expected to ship within 12 - 17 working days
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This thesis reports on the development of a fully integrated and
automated microsystem consisting of low-cost, disposable plastic
chips for DNA extraction and PCR amplification, combined with a
reusable glass capillary array electrophoresis chip, which can be
employed in a modular-based format for genetic analysis. In the
thesis, DNA extraction is performed by adopting a filter
paper-based method, followed by an "in-situ" PCR carried out
directly in the same reaction chamber of the chip without elution.
PCR products are then co-injected with sizing standards into
separation channels for detection using a novel injection
electrode. The entire process is automatically carried out by a
custom-made compact control and detection instrument. The author
thoroughly tests the system's performance and reliability by
conducting rapid genetic screening of mutations on congenital
hearing loss and pharmacogenetic typing of multiple
warfarin-related single-nucleotide polymorphisms. The successful
development and operation of this microsystem establishes the
feasibility of rapid "sample-in-answer-out" testing in routine
clinical practice.
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