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Cytokines and Growth Factors in Blood Transfusion - Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord Nederland (Paperback, Softcover reprint of the original 1st ed. 1997)
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Cytokines and Growth Factors in Blood Transfusion - Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord Nederland (Paperback, Softcover reprint of the original 1st ed. 1997)
Series: Developments in Hematology and Immunology, 32
Expected to ship within 10 - 15 working days
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Cytokines are cellular growth factors which also provide
communication between cells and their milieu. This clearly is an
exciting area in modern medicine that will have significant impact
on various facets of transfusion. Erythropoietin therapy stimulates
red cell production while thrombopoietin seems to positively affect
megakaryopoiesis and can be an added armamentarium for the
thrombocytopenic patient. Using haematnopoietic growth factors,
stem cells could be mobilized early to the peripheral blood for
collection and subsequent transplantation into haemato-oncology
patients instead of bone marrow transplantation. Using a cocktail
of cytokines in cell culture, stem cells could be expanded and
selected for therapy. Cytokines and growth factors can even be
modified, which may lead to successful gene therapy in
malignancies, including solid tumour vaccines. However, the
presence of cytokines in certain blood products could have
biological effects following transfusion, although its clinical
relevance needs to be ascertained. There is much potential for the
use of cytokines in the treatment of infections. Early diagnostic
methods are now available to monitor their levels and relevance. It
is likely that cytokines will increasingly play a role in therapy
and could develop our fundamental knowledge about the development
of T-cells. An ethical dilemma remains, however, regarding the use
of cytokines in healthy donors for harvesting suitable specific
cells. Longer clinical observation will be necessary to gather the
necessary information. Cytokines and growth factors in blood
transfusion was the theme of the 21st International Symposium in
Blood Transfusion, where twenty clinicians and scientists, experts
in their own fields, were invited to update the above information.
Their findings are presented in four sections in this volume:
Fundamental aspects - cytokines in development of T-cells, growth
factors in haematopoiesis, growth factor receptors and signal
transduction, cytokine response in platelet and whole blood
transfusions. Function, production and diagnosis &endash;
laboratory diagnostics of cytokines and growth factors, cytokines
in blood components, cytokines and growth factors in cell
expansions, cytokines for genetic modification towards gene
therapy, progenitor cells from healthy donors. Application in
clinical medicine &endash; clinical relevance of cytokines in
transfusion products, cytokines and growth factors in solid
tumours, gene therapy in malignancies, vaccine strategies inducing
T-cell immunity against tumours, cytokines in the treatment of
infections, thrombopoietin and megakaryopoiesis. Future potential
use in transfusion medicine &endash; erythropoietin,
immunotherapy, ethical aspects of the use of cytokines and growth
factors in donors, potential of cytokines and growth factors in
transfusion medicine.
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