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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation (Hardcover, 1st ed. 2021)
Loot Price: R2,957
Discovery Miles 29 570
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The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation (Hardcover, 1st ed. 2021)
Series: Progress in Inflammation Research, 87
Expected to ship within 10 - 15 working days
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TLR4 is one of the most important innate immunity receptors, its
function mainly consisting in the activation of inflammatory
pathways in response to stimulation by Pathogen-Associated
Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern
molecules (DAMPs). This volume critically reviews the different
types of TLR4 activators and inhibitors, discusses the role of
molecular aggregates in agonism/antagonism as well as the pivotal
role of the CD14 receptor in the modulation of TLR4 signal and the
molecular details and actors of the intracellular cascade. The book
presents the role of TLR4 in several pathologies, such as sepsis
and septic shock caused by receptor activation by gram-negative
bacterial lipopolysaccharide (LPS), in neurodegenerative and
neurological diseases such as Parkinson and Alzheimer's diseases,
and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of
TLR4 in neural stem cell-mediated neurogenesis and
neuroinflammation and in Human Induced Pluripotent Stem Cells and
Cerebral Organoids and discusses the emerging role of micro-RNA
(miRNA) regulation by TLR4.
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