Recent advances in technology have led to the unprecedented
accuracy in measurements of endogenous electric fields around sites
of tissue disruption. State-of-the-art molecular approaches
demonstrate the role of bioelectricity in the directionality and
speed of cell migration, proliferation, apoptosis, differentiation,
and orientation. New information indicates that electric fields
play a role in initiating and coordinating complex regenerative
responses in development and wound repair and that they may also
have a part in cancer progression and metastasis. Compiling current
research in this rapidly expanding field, Physiology of
Bioelectricity in Development, Tissue Regeneration, and Cancer
highlights relevant, cutting-edge topics poised to drive the next
generation of medical breakthroughs. Chapters consider methods for
detecting endogenous electric field gradients and studying applied
electric fields in the lab. The book addresses bioelectricity's
roles in guiding cell behavior during morphogenesis and
orchestrating higher order patterning. It also covers the response
of stem cells to applied electric fields, which reveals
bioelectricity as an exciting new player in tissue engineering and
regenerative medicine. This book provides an in-depth exploration
of how electric signals control corneal wound repair and skin
re-epithelialization, angiogenesis, and inflammation. It also
delves into the bioelectric responses of cells derived from the
musculoskeletal system, bioelectrical guidance of neurons, and the
beneficial application of voltage gradients to promote regeneration
in the spinal cord. It concludes with a discussion of
bioelectricity and cancer progression and the potential for novel
cancer biomarkers, new methods for early detection, and
bioelectricity-based therapies to target both the tumor and
metastatic cancer cells. This multidisciplinary compilation will
benefit biologists, biochemists, biomedical scientists, engineers,
dermatologists, and clinicians, or anyone else interested in
development, regeneration, cancer, and tissue engineering. It can
also serve as an ideal textbook for students in biology, medicine,
medical physiology, biophysics, and biomedical engineering.
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