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Molecular Diagnostics of Cancer (Paperback, 1993 ed.)
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Molecular Diagnostics of Cancer (Paperback, 1993 ed.)
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Present and potential future applications of new diagnostic
strategies basedon the direct or indirect detection of cancer genes
are delineated in this volume. Among the methodological aspects
covered are enzymatic target amplification by the polymerase chain
reaction and related techniques, DNA fingerprinting, transfer of
putative cancer genes in appropriate receipient cells, and recent
developments inthe application of monoclonal antibodies in
immunohistochemistry and immunoscintigraphy. The diagnostic and
functional implications of mutations in cancer genes such as ras
and p53 are described. The characterization of cancer genes and
their products is correlated with growth control anddissemination
of tumour cells by in vitro or clinical evidence. The contributions
in the present volume uptdate the information available on
established or newly described cancer genes, and may help manage
the transition from basic research to clinical practice.
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