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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Toll-Like Receptors - Practice and Methods (Paperback, Softcover reprint of the original 2nd ed. 2016)
Loot Price: R2,958
Discovery Miles 29 580
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Toll-Like Receptors - Practice and Methods (Paperback, Softcover reprint of the original 2nd ed. 2016)
Series: Methods in Molecular Biology, 1390
Expected to ship within 10 - 17 working days
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This second edition volume expands on the first edition with new
developments on Toll-Like Receptors (TLRs) controlling events such
as cross-priming of associated pattern recognition receptors,
post-transcriptional regulation, interaction with other cellular
and biologic systems, and cancer progression. This book is divided
into five sections: Part I outlines methods for TLR detection,
interaction, and intracellular trafficking; Part II describes
methods and assays to investigate how TLRs cross-prime other
pattern recognition receptors, including intracellular DNA
receptors and inflammasome formation; Part III highlights RNA
regulation, detailing how TLRs can induce RNA transcripts and
molecules such as lncRNAs and microRNAs; Part IV explores TLR
detection and activation in systems such as epithelial barrier
function, metabolism and the circadian clock, as well as cellular
systems including T and B lymphocytes; and Part V describes models
to delineate the role of TLRs in diseases such as dermatitis,
arthritis, and gastric cancer. Written in the highly successful
Methods in Molecular Biology series format, each chapter contains a
summary, a list of required materials, step-by-step, readily
reproducible laboratory protocols, useful notes to investigate TLRs
in cell culture, systems and disease, and tips on troubleshooting
and avoiding known pitfalls. Practical and cutting-edge, Toll-Like
Receptors: Methods and Protocols, Second Edition is a valuable
resource to any immunologist, molecular or medical biologist
working in a laboratory setting. It will add skill to both students
and the more advanced molecular biologist who wishes to learn a new
technique or move to a different area within their current
repertoire of practical knowledge.
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