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Prions - The New Biology of Proteins (Paperback)
Loot Price: R1,880
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Prions - The New Biology of Proteins (Paperback)
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Prion-related diseases, known as transmissible spongiform
encephalopathies (TSEs), are infectious, fatal neurodegenerative
disorders for which there is no cure, treatment, nor even a means
for early diagnosis. The horrific advent of Mad Cow Disease --
transmitted to humans through eating meat from steers sickened by
bovine spongiform encephalopathy --brought prion-related diseases
international attention. Exceptionally dramatic, these diseases
progressively and inexorably destroy the cognitive, motor, and
sensorial skills that are the essence of human beings. Prions: The
New Biology of Proteins provides a well-organized overview of what
is known about prion-related diseases. This comprehensive work
reviews the symptoms, epidemiology, and neuropathology of the
disease. It focuses on evidence supporting the idea that TSEs
result from a novel disease mechanism: transmission by replication
of the misfolding of a single protein in the absence of nucleic
acids. Following this hypothesis, the book examines the structure,
conversion, and mechanism of prion propagation and details its
cellular biology. It explores the transmission, discusses the
challenges involved with diagnosis, and considers various
therapeutic avenues that are presently being explored. A cohesive
volume that integrates the pioneering work of many researchers,
this book is authored by Claudio Soto, an internationally renowned
researcher whose innovative work has led to an increased
understanding of the heretical biology of prions and the
development of novel strategies for treating and diagnosing
neurodegenerative diseases. As protein misfolding diseases are his
specialty, Soto also looks at the phenomenon from a wider
perspective. He examines other diseases that display folding
aberrations, considers how commonly such aberrations occur in
nature, and asks readers to open their minds to consider the impact
of prions on broader areas of biology, public health, and
biotechnological
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