Myeloid-Derived Suppressor Cells and Cancer (Paperback, 1st ed. 2016)

The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	SpringerBriefs in Immunology
Release date:	March 2016
First published:	2016
Authors:	David Escors • James E. Talmadge • Karine Breckpot • Jo A. Van Ginderachter • Grazyna Kochan
Dimensions:	235 x 155 x 12mm (L x W x T)
Format:	Paperback
Pages:	102
Edition:	1st ed. 2016
ISBN-13:	978-3-319-26819-4
Categories:	Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	3-319-26819-8
Barcode:	9783319268194

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