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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Immune Tolerance (Hardcover, New)
Loot Price: R2,661
Discovery Miles 26 610
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Immune Tolerance (Hardcover, New)
Series: Cold Spring Harbor Perspectives in Biology
Expected to ship within 10 - 15 working days
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Immune tolerance ensures that the immune system responds to foreign
molecules and not to self-molecules. When tolerance breaks down,
severe, self-destructive diseases such as rheumatoid arthritis,
lupus, and multiple sclerosis may develop. Understanding the
mechanisms involved in establishing and maintaining immune
tolerance is essential for effectively treating these autoimmune
diseases. Written and edited by experts in the field, this
collection from Cold Spring Harbor Perspectives in Biology reviews
how self- tolerant T- and B-cell populations are produced. The
contributors discuss the elimination of autoreactive lymphocytes
during their development in the thymus and bone marrow, the
suppression of autoreactive cells by regulatory T cells in the
periphery, and intrinsic mechanisms that produce clonal anergy. The
roles of dendritic cells in antigen presentation and mechanisms
that prevent autoreactivity in natural killer cells are also
covered. Including discussions of autoimmune diseases, their
genetic bases, and therapeutic strategies, this volume is a
valuable reference for all immunologists and clinicians wishing to
understand or develop treatments for autoimmune diseases.
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