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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Neuropilin - From Nervous System to Vascular and Tumor Biology (Paperback, Softcover reprint of the original 1st ed. 2002)
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Neuropilin - From Nervous System to Vascular and Tumor Biology (Paperback, Softcover reprint of the original 1st ed. 2002)
Series: Advances in Experimental Medicine and Biology, 515
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Cell adhesion is one of the most important properties controlling
embryonic development. Extremely precise cell-cell contacts are
established according to the nature of adhesion molecules that are
expressed on the cell surface. The identifica tion of several
families of adhesion molecules, well conserved throughout evolu
tion, has been the basis of a considerable amount of work over the
past 20 years that contributed to establish functions of cell
adhesion in almost all organs. Nowadays, cell adhesion molecules
are not just considered as cellular glue but are thought to play
critical roles in cell signaling. Their ability to influence cell
proliferation, mi gration, or differentiation depends on both cell
surface adhesion properties and acti vation of intracellular
pathways. The next challenge will be to understand how these
molecules interact with each other to ensure specific functions in
the morphogen esis of very sophisticated systems. Indeed, by
exploring the cellular and molecular mechanisms of nervous system
development, the group of H. Fujisawa in Japan identified in 1987
an adhesion molecule, neuropilin, highly expressed in the neuro
pile of amphibian optic tectum. Ten years later, two groups
discovered that neuropilin is a receptor for guidance signals of
the semaphorin family. Axon guidance is a critical step during
brain development and the mechanisms ensuring growth cone
navigation are beginning to be well understood. The semaphorins are
bifunctional signals defining permissive or inhibitory pathways
sensed by the growth cone.
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