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Cell Membranes - Methods and Reviews Volume 3 (Paperback, Softcover reprint of the original 1st ed. 1987)
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Cell Membranes - Methods and Reviews Volume 3 (Paperback, Softcover reprint of the original 1st ed. 1987)
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This volume assembles reviews on topics in two major related areas.
One of these concerns the interactions of cells with substrata and
with other cells, which are mediated by the extracellular matrix
and soluble molecules. As described in this volume, these
interactions are responsible for controlling cell functions ranging
from embryogenesis and neural development to blood clotting. More
over, important properties of the extracellular matrix can be
modulated by the interdependent actions of tumor cells and
fibroblasts. The other major area of interest concerns the response
of cells to extracellular signals. Recent work has begun to reveal
how a remarkable diversity of cellular functions, including
neuronal, proliferative, membrane--cytoskeletal, and many other
kinds of re sponses, are elicited through the mediation of a
relatively small and interdepen dent set of second messenger
systems. These include both changes in cytoplasmic ionic balances
and activation of various kinds of protein kinases. Both subjects
are covered in this volume. The two areas are linked by the common
theme of cellular response to an external environment that is
sensed through cellular interactions with informational molecules,
which are soluble agents, as well as those that are components of
insoluble matrices. It is only recently that we have come to
appreciate the complex interplay between the matrix surrounding a
cell and the cell's response to hormones and growth factors. Thus,
we have tried to select examples in which this type of
extracellular integration may playa role."
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