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Biological Small Angle Scattering - Theory and Practice (Hardcover)
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Biological Small Angle Scattering - Theory and Practice (Hardcover)
Series: International Union of Crystallography Monographs on Crystallography, 29
Expected to ship within 12 - 17 working days
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Small angle solution scattering (SAS) is increasingly being applied
to biological problems. It is a complementary technique that, when
applied in appropriate circumstances with carefully structured
questions, can provide unique information not available from other
techniques. While small angle solution scattering has been around
for some time, a confluence of recent developments has dramatically
enhanced its power. Intense third generation X-ray sources, low
noise detectors, development of new algorithms and the
computational power to take advantage of these have all matured,
and use of free-electron x-ray laser sources is on the horizon.
Whole new classes of experiments and analyses have been created as
a result. These include the generation of molecular envelopes, the
ability to do time-resolved studies, and the ability to account for
structural changes using modelling based on the SAS data. The
technical improvements have also reduced the amount of time and
material needed to carry out an experiment. Beamtime at synchrotron
sources is in demand, workshops on the subject are popular and
researchers adopting the technique as part of their repertoire are
growing. With these in mind, this book was written to guide
structural biologists who may wish to adopt the technique,
understand its strengths and weaknesses or just have a general
interest in its potential.
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