Leading researchers review the activation of the mammalian immune
system by bacterial DNA and its immunostimulatory sequences (ISS),
and consider the applications of ISS in clinical medicine. The
authors survey the latest findings concerning the
receptor-recognition and signaling pathways triggered by ISS , the
process of cell activation, and the potential vaccination
strategies using ISS. Specific pharmaceutical applications
discussed include infectious disease (Hepatitis B, HIV, and
mycobacterial infections), allergy (asthma and conjunctivitis),
cancer (lymphoma), and inflammation and autoimmunity (arthritis and
colitis).
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