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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Immunogenetics - Methods and Applications in Clinical Practice (Paperback, Softcover reprint of the original 1st ed. 2012)
Loot Price: R3,449
Discovery Miles 34 490
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Immunogenetics - Methods and Applications in Clinical Practice (Paperback, Softcover reprint of the original 1st ed. 2012)
Series: Methods in Molecular Biology, 882
Expected to ship within 10 - 15 working days
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The HLA molecules are important regulators of the immune response
through mediating antigen presentation and interaction between key
immune mediating cells. They are also the major histocompatibility
barriers to transplantation, which is the clinical paradigm of the
self versus non self concept. It is now recognized that this
diverse range of gene systems involved in the control of the immune
response have been shown to be important in many aspects of
clinical practice. As a result many new molecular and cellular
methods have been developed for identifying these genes and their
polymorphisms, and immunogenetic laboratories specializing in these
methods have developed to support transplantation and other
clinical programs. Immunogenetics: Methods and Applications in
Clinical Practice focuses on methods for human clinical practice.
The emphasis rests on those assays which are of established or
potential clinical utility and are likely to be included in the
repertoire of tests provided by a routine diagnostic and service
laboratory. This volume also contains several review chapters of
the MHC complex, the KIR complex, the human immunoglobulin
allotypes, as well as reviews of the methods for the detection of
alloreactive NK cells and the detection of HLA antibodies by solid
phase assays. Written in the successful Methods in Molecular
Biology (TM) series format, chapters include introductions to their
respective topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible protocols, and notes on
troubleshooting and avoiding known pitfalls. Authoritative and
easily accessible, Immunogenetics: Methods and Applications in
Clinical Practice seeks to serve both the immunogenetics community
and the wider scientific community with a collection of detailed
information and helpful tips attained by many years of experience
in the field.
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