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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
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Human Retrotransposons in Health and Disease (Hardcover, 1st ed. 2017)
Loot Price: R4,811
Discovery Miles 48 110
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Human Retrotransposons in Health and Disease (Hardcover, 1st ed. 2017)
Expected to ship within 12 - 17 working days
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This unique book explores the role of retrotransposons in human
health and disease. The ability of retrotransposons to affect the
structure of human genes is recognized since the late 80's.
However, the advances of deep-sequencing technologies have shed new
light on the extent of retrotransposon-mediated genome variations.
These progresses have also led to the discovery that
retrotransposon activity is not restricted to the germline -
resulting in inheritable genetic variations - but can also mobilize
in somatic tissues, such as embryonic stem cells, neuronal
progenitor cells, or in many cancers. This book covers topics
related to the effects of retrotransposon insertions, and their
consequences on germline and somatic genome dynamics, but also
discuss the role and impact of retrotransposons sequences in a
broader context, including a number of novel topics that emerged
recently (long non-coding RNA, neuronal disorders, exaptation) with
unexpected connections between retrotransposons, stem cell
maintenance, placentation, circadian cycles or aging.
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