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Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy > Cytology
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Transcriptional and Translational Regulation of Stem Cells (Hardcover, 2013 ed.)
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Transcriptional and Translational Regulation of Stem Cells (Hardcover, 2013 ed.)
Series: Advances in Experimental Medicine and Biology, 786
Expected to ship within 12 - 17 working days
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Stem cells are central to the development and homeostasis of
metazoan tissues and play roles at multiple times within a
diversity of organs during the lifetime of an animal. A key goal of
regenerative medicine is the in vivo repair of organs damaged by
disease or injury. In order to facilitate this goal we need to
understand how stem cells are generated, what factors maintain them
in their respective tissues and how their differentiation is
regulated. In this volume, leading researchers discuss the nature
of stem cells and pluripotency and how this state can be
experimentally induced. Stem cell maintenance, proliferation and
differentiation is under tight regulation as excess stem cell
proliferation could facilitate tumour formation and conversely loss
of stem cells or failure of differentiation could disrupt tissue
homeostasis or repair. Hence, stem cells are regulated by multiple
layers of molecular control and this volume discusses
transcriptional, translational, epigenetic, cell signalling and
microRNA modalities that affect stem cell behaviour. Many of the
underlying key principles of stem cell biology were discovered by
genetic analysis of invertebrate systems and chapters in this
volume describe regulation of the germline in C. elegans and in the
digestive system, central nervous system and germline of
Drosophila. The molecular processes that regulate regenerative
organ systems from all three of the vertebrate germ layers are
described with emphasis on the male germline, nervous system,
epidermis, intestine, haematopoietic system and derivatives of the
mesoderm. Several chapters also focus on molecular families that
have been implicated in controlling a range of stem cell types
including the JAK-STAT, Wnt and Notch signalling pathways; Myc, Myb
and nuclear receptor transcriptional regulators; the Musashi family
of RNA-binding proteins; microRNAs and epigenetic regulators. This
volume will provide access to the current state of re
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