TOR, the Target of Rapamycin was discovered a little over ten
years ago in a genetic screen in S. cerevisiae in search of mutants
resistant to the cytostatic effects of the antimycotic, rapamycin.
Recent studies have placed TOR at the interface between nutrient
sensing and the regulation of major anbolic and catabolic
responses. The editors have gathered the leading figures in the
field of TOR and its role in cellular homeostasis and human
diseases.
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