Pertussis Infection and Vaccines - Advances in Microbiology, Infectious Diseases and Public Health Volume 12 (Paperback, 1st ed. 2019)

This book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of B. pertussis, while the following chapters focus on the role of B. pertussis virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines. Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replaced older-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death. This book is a valuable resource for researchers and clinicians in the field of medical microbiology, vaccine research and infectious diseases.

General

Imprint:	Springer Nature Switzerland AG
Country of origin:	Switzerland
Series:	Advances in Experimental Medicine and Biology, 1183
Release date:	2021
First published:	2019
Editors:	Giorgio Fedele • Clara Maria Ausiello
Dimensions:	254 x 178mm (L x W)
Format:	Paperback
Pages:	170
Edition:	1st ed. 2019
ISBN-13:	978-3-03-033251-8
Categories:	Books > Medicine > Other branches of medicine > Pathology > Medical microbiology & virology Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > Bacteriology Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases > General
LSN:	3-03-033251-9
Barcode:	9783030332518

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