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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases
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Pertussis Infection and Vaccines - Advances in Microbiology, Infectious Diseases and Public Health Volume 12 (Paperback, 1st ed. 2019)
Loot Price: R2,789
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Pertussis Infection and Vaccines - Advances in Microbiology, Infectious Diseases and Public Health Volume 12 (Paperback, 1st ed. 2019)
Series: Advances in Experimental Medicine and Biology, 1183
Expected to ship within 10 - 15 working days
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This book provides a comprehensive overview of pertussis - also
known as whooping cough. The first part discusses the evolution the
genus Bordetellae and the molecular epidemiology of B. pertussis,
while the following chapters focus on the role of B. pertussis
virulence factors in infection and disease and on the mechanisms of
the immune response to infection and vaccination. The book also
explores the prevention and control of the disease as well as its
clinical management, with the finally section addressing
vaccination, from improved immunization strategies to novel
vaccines. Pertussis remains one of the most poorly controlled
vaccine-preventable diseases around the globe. Universal
vaccination has dramatically reduced its incidence but has failed
to bring it completely under control. In recent decades, changes in
pertussis epidemiology have been noted, likely related to the use
of acellular pertussis vaccines, which in many countries have
replaced older-generation, whole-cell pertussis vaccines. Several
years after their introduction, it is becoming apparent that
immunity conferred by acellular vaccines wanes more rapidly than
expected. Unlike whole-cell vaccines, acellular vaccines, while
protecting against the disease, do not seem to prevent colonization
and transmission. Increasing incidence among adolescents and adults
makes them a reservoir for transmission to unimmunized infants, who
in turn are at risk of severe disease and death. This book is a
valuable resource for researchers and clinicians in the field of
medical microbiology, vaccine research and infectious diseases.
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