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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > Radiotherapy
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Chemotherapy and Radiotherapy of Gastrointestinal Tumors (Paperback, Softcover reprint of the original 1st ed. 1981)
Loot Price: R2,264
Discovery Miles 22 640
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Chemotherapy and Radiotherapy of Gastrointestinal Tumors (Paperback, Softcover reprint of the original 1st ed. 1981)
Series: Recent Results in Cancer Research, 79
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Attempts to influence survival of patients with colorectal cancer
(CRC) by adjuvant chemotherapy are limited by the variability of
survival in different prognostic groups [4] and the paucity of
drugs that have shown activity in the advanced disease [10]. Of the
few drugs which are active in the advanced disease, only
5-fluorouracil (5-FU) and razoxane
"+/-1,2-bis(3,4-dioxopiperazin-1-yl)propane) are suitable for
long-term adjuvant treatment [2, 9]. 5-FU has been widely and
intensively studied as adjuvant chemotherapy in CRC [7], but there
is no unanimity that it has even the marginal influence on survival
that has been claimed [3, 10]. Razoxane has not previously been
tested for adjuvant or maintenance treatment in CRC. It has however
a number of biological activities which might be thought useful in
the treatment of residual or minimal tumours [1] and which might
therefore make it useful as an adjuvant. Thus it specifically
prevents tumour dissemination and metastases in some tumours and
normalizes the neovasculature which the tumours induce [6, 8, 11].
The drug is not cytotoxic in the usual sense, does not affect
non-dividing cells, and only blocks cell division during a brief
period of the cell cycle in late G and/or early mitosis [12]. It
does so non-selectively and most cells capable of 2 division
examined so far have been affected by the drug. Even affected cells
however are not destroyed immediately, but may increase in size and
become multinucleate [5].
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