Malaria has defeated previous efforts at eradication and remains
a massive global public health problem despite being readily
preventable and treatable. It is a devastating disease that also
extracts huge economic costs from the poorest countries in endemic
regions.
Starting with an overview of the disease and its current
political, financial and technical context, this "Milestones in
Drug Therapy" volume describes the history, chemistry, mechanisms
of action and resistance, preclinical and clinical use,
pharmacokinetics and safety and tolerability of the current range
of antimalarial drugs. There is particular emphasis on artemisinins
and related peroxides, as these drugs have now become the frontline
treatment for malaria. Next generation antimalarials, molecular
markers for detecting resistance, the importance of diagnostics and
disease prevention are also covered in detail.
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