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Transacting Functions of Human Retroviruses (Paperback, Softcover reprint of the original 1st ed. 1995)
Loot Price: R2,777
Discovery Miles 27 770
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Transacting Functions of Human Retroviruses (Paperback, Softcover reprint of the original 1st ed. 1995)
Series: Current Topics in Microbiology and Immunology, 193
Expected to ship within 10 - 15 working days
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Total price: R2,797
Discovery Miles: 27 970
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The genome of retroviruses contains three major coding regions for
virion proteins, gag, pol and env. Gag encompasses information for
nonglycosylated viral proteins that form the matrix, the capsid and
the nucleoprotein structures. From pol derive reverse transcriptase
and integrase, and env codes for the surface glycoproteins of the
virion which consist of a transmembrane and a surface domain,
linked by disulfide bonds. A viral protease is derived eitherfrom
the gagorfrom the pol coding region, depending on the virus. Simple
retroviruses contain only this elementary gag, pol, and env coding
information. Once integrated, they are able to multiply
efficiently, using the cellular transcriptional and replication
machineries without intervention of viral transacting factors. Most
oncogenic retroviruses belong in this category. Complex
retroviruses, on the other hand, encode additional nonstructural
proteins from multiply spliced messages. These proteins play
important regulatory roles in the life cycle of the virus. They
function as transacting factors that, in concert with cellular
regulatory proteins, control viral gene expression and function and
are essential components in the replication of complex
retroviruses. To this category belong the lentiviruses, the
spumaviruses and a group of oncogenic retroviruses that includes
human T cell leukemia virus (HTLV) and bovine leukosis virus(BLV).
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