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Chemotactic Cytokines - Biology of the Inflammatory Peptide Supergene Family (Paperback, Softcover reprint of the original 1st ed. 1991)
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Chemotactic Cytokines - Biology of the Inflammatory Peptide Supergene Family (Paperback, Softcover reprint of the original 1st ed. 1991)
Series: Advances in Experimental Medicine and Biology, 305
Expected to ship within 10 - 15 working days
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The existence of a new family of chemotactic cytokines was realised
in 1987 following the isolation and structural determination by
several groups of a peptide consisting of 72 amino acids which was
a potent activator of neutrophils and a chemotactic agent for
lymphocytes. The first symposium of this series was held at the
Royal College of Surgeons of England in December 1988, entitled
Novel Neutrophil Stimulating Peptides, and brought together the
majority of the laboratories which had published in this area, see
Immunology Today 10: 146-147(1989). Since the first symposium there
has been a dramatic increase in our knowledge of the biology of
this family of structurally related peptides. The Second
International Symposium on Chemotactic Cytokines was held at the
Royal College of Surgeons of England in June 1990. The aim of this
symposium was to provide both a forum for discussion and to
determine whether this knowledge can be utilised in the design of
novel therapeutic strategies for the treatment of inflammatory
disorders. Although the majority of studies have been concerned
with the regulation of these peptides at the molecular and cellular
level, there is now evidence to suggest that specific members of
this superfamily have a role in the pathogenesis of a number of
diverse diseases including arthritis, psoriasis, atherosclerosis,
wound repair, inflammatory lung diseases and glomerulonephritis.
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