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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Ion Channels - From Structure to Function (Hardcover)
Loot Price: R6,676
Discovery Miles 66 760
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Ion Channels - From Structure to Function (Hardcover)
Expected to ship within 12 - 17 working days
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Ion channels are intimately involved in the everyday physiological
functions that enable us to live a full and varied life. When
disease strikes, malfunction of ion channels or their dependent is
often involved, either as the cause or the effect of the illness.
Thus, billions of dollars have been, and still are being, invested
in research to understand the physiological and pathophysiological
functions of ion channels in an attempt to develop novel
therapeutic treatments for a wide range of diseases.
This book provides a comprehensive overview of ion channel
structure and function. It comprises two major parts. Part one is
an introductory overview of the ion channel superfamily and the
generic aspects of ion channel function. This part also reviews the
methodologies by which ion channel function can be studied from the
perspective of performing detailed biophysical characterization
through to the deployment of high throughput approaches for
identifying novel ion channel ligands.
Part two of the book provides an in-depth review of the individual
ion channel subfamilies and, as such, is subdivided into four broad
sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated
Ion Channels, Intracellular Ligand-Gated Ion Channels, and
Polymodal-Gated Ion Channels, with each chapter focused on specific
family members. These chapters have been written by world leading
experts and provide a detailed overview of the structure,
biophysics, localization, pharmacology, physiology, and disease
relevance of each particular ion channel subfamily.
Reviewing both the basic principles of ion channel function and
providing a detailed up-to-date review of the phsyiological and
pharmacological aspects of individual ion channel sub-families,
this book constitutes both an excellent introduction to the field
for non-specialists, as well as a highly valuable reference text
for experienced researchers already working in the ion channel
area.
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