The Textbook of Ion Channels is a set of three volumes providing a
wide-ranging reference source on ion channels for students,
instructors, and researchers. Ion channels are membrane proteins
that control the electrical properties of neurons and cardiac
cells, mediate the detection and response to sensory stimuli like
light, sound, odor, and taste, and regulate the response to
physical stimuli like temperature and pressure. In non-excitable
tissues, ion channels are instrumental for the regulation of basic
salt balance that is critical for homeostasis. Ion channels are
located at the surface membrane of cells, giving them the unique
ability to communicate with the environment, as well as the
membrane of intracellular organelles, allowing them to regulate
internal homeostasis. Ion channels are fundamentally important for
human health and diseases, and are important targets for
pharmaceuticals in mental illness, heart disease, anesthesia, pain
and other clinical applications. The modern methods used in their
study are powerful and diverse, ranging from single ion-channel
measurement techniques to models of ion channel diseases in
animals, and human clinical trials for ion channel drugs. Volume I,
Part 1 covers fundamental topics such as the basic principles of
ion permeation and selectivity, voltage-dependent, ligand-dependent
and mechano-dependent ion channel activation mechanisms, the
mechanisms for ion channel desensitization and inactivation and
basic ion channel pharmacology and inhibition. Volume I, Part 2
aims to offer a practical guide of cardinal methods for researching
ion channels, including heterologous expression and voltage-clamp
and patch-clamp electrophysiology, isolation of native currents
using patch-clamp, modelling ion channel gating, structures and its
dynamics, crystallography and cryo- electron microscopy,
fluorescence and paramagnetic resonance spectroscopy methods and
genetics approaches in model organisms. All three volumes give the
reader an introduction to fundamental concepts needed to understand
the mechanism of ion channels, a guide to the technical aspects of
ion channel research, offer a modern guide to the properties of
major ion channel families, and include coverage of key examples of
regulatory, physiological, and disease roles for ion channels.
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