The Textbook of Ion Channels is a set of three volumes that
provides a wide-ranging reference source on ion channels for
students, instructors, and researchers. Ion channels are membrane
proteins that control the electrical properties of neurons and
cardiac cells, mediate the detection and response to sensory
stimuli like light, sound, odor, and taste, and regulate the
response to physical stimuli like temperature and pressure. In
non-excitable tissues, ion channels are instrumental for the
regulation of basic salt balance that is critical for homeostasis.
Ion channels are located at the surface membrane of cells, giving
them the unique ability to communicate with the environment, as
well as the membrane of intracellular organelles, allowing them to
regulate internal homeostasis. Ion channels are fundamentally
important for human health and diseases, and are important targets
for pharmaceuticals in mental illness, heart disease, anesthesia,
pain and other clinical applications. The modern methods used in
their study are powerful and diverse, ranging from single
ion-channel measurement techniques to models of ion channel
diseases in animals, and human clinical trials for ion channel
drugs. Volume II starts with ion channel taxonomy and features
coverage of major ion channel families and describes the
physiological role, structural components, gating mechanisms and
biophysics, permeation and selectivity, regulation, pharmacology
and roles in disease mechanisms. Channels in this volume include
voltage-activated sodium, calcium and potassium channels,
inward-rectifier and two-pore domain potassium channels,
calcium-activated potassium channels, cyclic-nucleotide gated
channels, pacemaker ion channels, chloride channels, the
ligand-gated receptors activated by acetylcholine, glutamate,
5-HT3, GABA and glycine, acid-sensing channels, P2X receptors, TRP
channels, store-operated channels, pressure-activated piezo
channels, ryanodine receptors and proton channels. All three
volumes give the reader an introduction to fundamental concepts
needed to understand the mechanism of ion channels, a guide to the
technical aspects of ion channel research, offer a modern guide to
the properties of major ion channel families, and include coverage
of key examples of regulatory, physiological, and disease roles for
ion channels.
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