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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Antiviral Chemotherapy 5 - New Directions for Clinical Application and Research (Paperback, Softcover reprint of the original 1st ed. 1999)
Loot Price: R4,365
Discovery Miles 43 650
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Antiviral Chemotherapy 5 - New Directions for Clinical Application and Research (Paperback, Softcover reprint of the original 1st ed. 1999)
Series: Advances in Experimental Medicine and Biology, 458
Expected to ship within 10 - 15 working days
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Scientists and clinicians attending the last "New Directions in
Antiviral Therapy" conference in late 1994 could hardly have
predicted the revolution in the management of patients with HIV
infection that has occurred since. Two new classes of
antiretrovirals have been licensed, the second-site RT inhibitors
and the protease inhibitors; the long in cubation period of active
HIV infection, when the infection is clinically latent, is now un
derstood to be a period of intense viral replication and turnover
of CD4 lymphocytes; measurements of HI V RNA concentration in
plasma have been shown to be essential tools for monitoring the
course of HIV infection, deciding when to treat, and assessing the
re sults of treatment; and finally, combinations of
antiretrovirals, particularly combinations including protease
inhibitors, have been shown to have dramatically beneficial effects
on patients with HIV infection. These advances, coupled with new
drugs for the management of herpesvirus infections, have made
dramatic differences in the quality and length of life of
HIV-infected patients. Additional advances have been made since
1994 in the prevention or management of influenza virus
(zanamavir), respiratory syncytial virus (palvizumab), hepatitis B
virus (lamivudine and famciclovir), and enterovirus infections
(pleconaril). It is difficult to re member that only slightly more
than a decade ago there were only a handful of antiviral agents
available (none of which were antiretrovirals), and a number of
those were either highly toxic, of dubious efficacy, or both."
General
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