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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Gene Vaccines (Paperback, Softcover reprint of the original 1st ed. 2012)
Loot Price: R4,539
Discovery Miles 45 390
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Gene Vaccines (Paperback, Softcover reprint of the original 1st ed. 2012)
Expected to ship within 10 - 15 working days
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The induction of antigen-specific immune responses after in vivo
transfection with expression plasmids has triggered a revolution of
vaccine research. After a first hype, evoked by the fascinating
options of this method, clinical studies did not reach the
ambitious aims and a phase of disillusion ensued. It became obvious
that Gene vaccines displayed a weaker immunogenicity in humans than
had been observed in the mouse models. Meanwhile these hurdles have
been overcome and gene vaccines undergo a renaissance. The present
book gives an update of the "world of naked gene vaccines", namely
DNA and RNA vaccines. Its content ranges from general mechanisms,
inherent immunostimulatory properties and the vast potential to
modulate immune responses, to recent successful clinical studies
and approved veterinary gene vaccines. Beyond the state-of-the-art
of genetic immunization, the reader will be stimulated with a
chapter addressing "burning questions".
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