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Foodborne Pathogens - Virulence Factors and Host Susceptibility (Hardcover, 1st ed. 2017)
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Foodborne Pathogens - Virulence Factors and Host Susceptibility (Hardcover, 1st ed. 2017)
Series: Food Microbiology and Food Safety
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Foodborne illnesses continue to be a major public health concern.
All members of a particular bacterial genera (e.g., Salmonella,
Campylobacter) or species (e.g., Listeria monocytogenes,
Cronobacter sakazakii) are often treated by public health and
regulatory agencies as being equally pathogenic; however, this is
not necessarily true and is an overly conservative approach to
ensuring the safety of foods. Even within species, virulence
factors vary to the point that some isolates may be highly
virulent, whereas others may rarely, if ever, cause disease in
humans. Hence, many food safety scientists have concluded that a
more appropriate characterization of bacterial isolates for public
health purposes could be by virotyping, i.e., typing
food-associated bacteria on the basis of their virulence factors.
The book is divided into two sections. Section I, "Foodborne
Pathogens and Virulence Factors," hones in on specific virulence
factors of foodborne pathogens and the role they play in regulatory
requirements, recalls, and foodborne illness. The oft-held paradigm
that all pathogenic strains are equally virulent is untrue. Thus,
we will examine variability in virulence between strains such as
Listeria, Salmonella, Campylobacter, Cronobacter, etc. This section
also examines known factors capable of inducing greater virulence
in foodborne pathogens. Section II, "Foodborne Pathogens, Host
Susceptibility, and Infectious Dose" , covers the ability of a
pathogen to invade a human host based on numerous extraneous
factors relative to the host and the environment. Some of these
factors include host age, immune status, genetic makeup, infectious
dose, food composition and probiotics. Readers of this book will
come away with a better understanding of foodborne bacterial
pathogen virulence factors and pathogenicity, and host factors that
predict the severity of disease in humans.
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