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Control of Innate and Adaptive Immune Responses during Infectious Diseases (Hardcover, 2012 Ed.)
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Control of Innate and Adaptive Immune Responses during Infectious Diseases (Hardcover, 2012 Ed.)
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Upon infection the host needs to mount vigorous immune response
against pathogen in order to successfully control its replication.
However, once the infectious agent is controlled or eliminated,
host cells need to signal the immune system to slow or cease its
activities. While vast knowledge has been accumulated through the
years on the mechanisms involved in the initiation and effector
phases of the immune responses, the pathways triggered in order to
modulate or end innate and acquired immunity are becoming more
evident as evidence for its relevance comes to surface. Due to its
biological power, evidence has surfaced indicating that eventually
pathogens may take advantage of such regulatory pathways in order
to escape effector mechanisms and progress to persistence. This
book will discuss several cellular pathways involved in controlling
immune response in the context of infectious diseases, their
biological consequences and potential "hijack" of these pathways
for the benefit of pathogen leading towards pathogen persistence as
opposed to clearance.
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