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Nephrocalcinosis Calcium Antagonists and Kidney (Paperback, Softcover reprint of the original 1st ed. 1988)
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Nephrocalcinosis Calcium Antagonists and Kidney (Paperback, Softcover reprint of the original 1st ed. 1988)
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The effect of calcium antagonists on heart muscle and blood
circulation is the reason that they have found widespread clinical
application for a number of years. Less well known, in contrast, is
the effect this group of substances has on the kidneys, both on
kidney cells and the blood flow through the kidneys. This effect
was the subject of a workshop we organized in Tiibingen in June
1986. Different groups studied the effects of these substances,
especially in animals, on the processing of calcium by the kidney
cells and on blood flow. A possible explanation is that the calcium
antagonists block the influx of calcium through special cell
canals, especially the cells of the distal tubule. It is necessary
to test whether there is a blockade or only a reduction in the
passage of calcium. Our understanding of the effect of calcium
antagonists is in large part based on the results of morphologic,
physiologic, and pharmacologic studies of calcium in the kidneys.
The particular processes involved in nephrocalcinosis are special
objects of study with regard to calcium antagonists. This book
presents the results of experimental studies of the effect of
calcium antagonists on nephrocalcinosis and acute renal failure
after ischemia. In this context, the clinician is particularly
interested in the use of calcium antagonists to protect against the
kidney in urolithiasis, in acute renal failure and during kidney
transplantation. The book is thus of interest to urologists and
nephrologists as well as pharmacologists. biochemists,
physiologists, and others in research.
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