The Polymerase Chain Reaction (Paperback, 1994 ed.)

James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. "It has not escaped our notice," Francis wrote, "that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material." By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains that are complementary to each other. Each chain could then act ." . . as a template for the formation on itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before" and, moreover, " ..."

General

Imprint:	Birkhauser Boston
Country of origin:	United States
Release date:	March 1994
First published:	1994
Editors:	Kary B. Mullis
Foreword by:	J.D. Watson
Editors:	Francois Ferre • Richard A. Gibbs
Dimensions:	254 x 178 x 29mm (L x W x T)
Format:	Paperback
Pages:	458
Edition:	1994 ed.
ISBN-13:	978-0-8176-3750-7
Categories:	Books > Science & Mathematics > Biology, life sciences > Molecular biology Books > Professional & Technical > Biochemical engineering > Biotechnology > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > General
LSN:	0-8176-3750-8
Barcode:	9780817637507

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