Mass Spectrometry: A Foundation Course is a textbook covering the
field of mass spectrometry across the chemical, physical,
biological, medical and environmental sciences. Sufficient depth is
provided for the reader to appreciate the reasons behind and basis
for particular experiments. It is uniquely and logically organised
to enable the book to form the basis for a university course in
mass spectrometry at the undergraduate or postgraduate level. This
is achieved by combining specific core sections coupled to optional
areas of study tailored to students of the chemical, physical,
biological, medical and environmental sciences. Recommended course
structures are provided in the front of the book.
Dedicated chapters are included on: organic mass spectrometry;
ion chemistry - to emphasise the role of mass spectrometry in
fundamental chemistry and physics; biological mass spectrometry
including proteomics; mass spectrometry in medicine, environmental
and surface science and accelerator mass spectrometry, to emphasise
the importance of these areas. Each chapter concludes with key
references and additional recommended reading material, making the
book an excellent springboard to further study.
Highly readable, easy-to-use and logically presented, Mass
Spectrometry: A Foundation Course is an ideal text for students and
for those who work with mass spectrometers who wish to gain a solid
understanding of the basics in modern mass spectrometry.
"From the reviews: "
"
Although I am not a fan or either "eras" or "omes" you hear all
the time that we now live in the era of the proteome. Setting aside
the issues of what constitutes proteomics (after all people have
been sequencingproteins and studying their structure for a few
years nowA... ), and whether the regular appearance of reports of
another organisms genome sequence prevents you from saying that we
are in the post-genomic era, it is clear that the analysis of large
numbers of complex protein mixtures is just about in all of our
reach. This is going to be a very important way to look for
molecular markers and targets in the battle against cancer.
The bedrock of proteomic analysis is mass spectrometry, which
allows you to accurately measure the mass of molecules. In
proteomics this can mean studying the mass of intact proteins,
which can give you a clue as to their identity, and help you
rapidly identify modifications. It can also mean busting the
protein into many component fragments and measuring their mass,
which can lead to protein identification via clever algorithms that
compare measured fragment sizes to predicted ones using the genome
databases.
One sign that this technology is about to become widely distributed
is the appearance of relatively small softcover textbooks for
beginners. These represent a reasonable first step towards
initiation in this area, for those of us who left school a few
years ago. There are two recent ones that I have read that I found
to be particularly useful.
The first is Mass Spectrometry: A Foundation Course by Kevin
Downard of Sydney, Australia.
This book covers many aspects of the field in under 200 pages,
and has a handy guide to what sections are useful to individuals
from different disciplines. It starts with history and concepts,
and then devotes a significant amount of space to the
instrumentation. This is very useful to anyone who has been to a
massspectrometry meeting and trade show or even browsed the
relevant companies websites. Dr. Downard covers the basics of how
each variant works, and what it is best suited for, and includes
discussion of single and tandem instruments. By the end you'll be
able to raise your eyebrows appreciatively the next time a salesman
fires an acronym and figure at you (or at least you'll know where
to look it up once you have reached a safe distance). The second
half of the book looks at specific applications for mass
spectrometry, and here you can read selectively on what you are
interested in doing. The sections on protein analysis were good
primers. The book is quite mathematical throughout, and since I
have no talent in this direction, the equations merely confirmed my
deficiency in this area - to those of you who like it, it is there.
Then at the end are a series of very useful appendices that show
amino acid masses, masses of common protein modifications and
websites for further reading or for protein identification, among
other useful things. I recommend this book highly to anyone looking
for a first port of call on the journey to mass spectrometry."
[Oliver Bogler]
"From the reviews: "
"
Mass spectrometry today plays a vital role in a range of
scientific disciplines including synthetic and physical organic
chemistry, biological and medicinal chemistry and environmental and
surface sciences.
In the past two decades, advances in instrument design and in
computer control have brought the technique out of the basements of
chemical laboratories and onto the bench of modern analytical
laboratories. Advances in linking mass spectrometry to both gas and
liquid chromatography have meantthat chromatographers have had to
learn the extra dimensions of experiment that such
multi-dimensional techniques can provide. Mass spectrometry is not
now confined to research but is being increasingly used by
environmental agencies, clinical chemistry laboratories and
anywhere advanced analytical chemistry is required.
Few introductory texts have kept up with these advances,
although there have been recent specialist texts on biotechnology
and on LC/MS. Downard's book seeks to provide a basis for
instruction of undergraduate and new postgraduate students. His
philosophy has been to write introductory sections for all the
basic aspects of mass spectrometry - his 'core' course - and to add
sections for the major areas in which it is employed. These
additional sections can be optionally added to the core course, as
desired. Downard provides a menu suggesting how they can be put
together. Each core section is well written and covers the basis of
the science concerned very satisfactorily.
The sections that describe the different applications are
necessarily condensed and the author tries to give extra reading
with a good set of references.
Students who plan to use mass spectrometry in proteomic research
will require much further assistance and the same goes for
metabolomic/metabonomic studies and for users of quantitative
analysis, but, for both, the core sections will be valuable." [Tony
Mallet]
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