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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Ex Vivo Cell Therapy (Hardcover)
Loot Price: R3,890
Discovery Miles 38 900
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Ex Vivo Cell Therapy (Hardcover)
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Over the last two decades advances in the understanding of disease
at a cellular and molecular level has led to innovative therapies
that are based on the administration of cells which have been
modified outside of the body. Ex vivo cell therapy is in essence
gene therapy delivered by transfer of therapeutic genes to cells in
culture, which are then given to the patient to treat fatal
infections such as AIDS, or other conditions such as cancer or
genetic diseases. These manipulations include the purification and
culture of therapeutic cell subtypes, as well as elimination of
cells which cause disease (cancer cells or immune cells reacting to
the body itself). Gene therapy can be delivered by transfer of
therapeutic genes to cells in culture, which are then given to the
patient to treat fatal infections such as AIDS, cancer or genetic
diseases. For small-scale laboratory methods to become clinically
applicable processes, these new therapies require efficient
technologies for cell separation, cell production in culture and
gene transfer. This book integrates the recent advances in
biological and clinical research with developments in cell-based
technologies to provide a comprehensive review for clinicians,
researchers, biotechnologists and biomedical engineers working in
this rapidly developing area. The biotechnology and pharmaceutical
industry requires a broad perspective for development of future
technologies, and this text will provide then with an excellent
overview of this rapidly evolving field.
Key Features
* Comprehensive review by leading researchers
* Hematopoietic stem cell development: transcriptional control,
signaling pathways, hematopoietic growth factors and adhesion
molecules
* Clinical developments: hematopoietic stem cell transplantation,
cellular immunotherapy and gene therapy
* Enabling technologies: cell separation, bioreactors, and gene
transfer regulatory issues
General
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