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Books > Professional & Technical > Biochemical engineering > Biotechnology
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Organelle and Molecular Targeting (Hardcover)
Loot Price: R6,779
Discovery Miles 67 790
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Organelle and Molecular Targeting (Hardcover)
Expected to ship within 12 - 19 working days
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We have surpassed the omics era and are truly in the Age of
Molecular Therapeutics. The fast-paced development of SARS-CoV-2
vaccines, such as the mRNA vaccines encoding the viral spike
protein, demonstrated the need for and capability of molecular
therapy and nanotechnology-based solutions for drug delivery. In
record speed, the SARS-CoV-2 viral RNA genome was sequenced and
shared with the scientific community, allowing the rapid design of
molecular therapeutics. The mRNA vaccines exploit the host cell
endoplasmic reticulum to produce viral spike proteins for antigen
presentation and recognition by the innate and adaptive immune
system. Lipid nanoparticles enable the delivery of the fragile,
degradation-sensitive nucleic acid payloads. Molecular-based
therapeutics and nanotechnology solutions continue to drive the
scientific and medical response to the COVID-19 pandemic as new
mRNA, DNA, and protein-based vaccines are developed and approved
and the emergency use approved vaccines are rapidly manufactured
and distributed throughout the globe. The need for molecular
therapies and drug delivery solutions is clear, and as these
therapies progress and become more specialized there will be
important advancements in organelle targeting. For example, using
organelle targeting to direct lipid nanoparticles with mRNA
payloads to the endoplasmic reticulum would increase the efficacy
of mRNA vaccines, reducing the required dose and therefore the
biomanufacturing demand. Likewise, improving the delivery of DNA
therapeutics to the nucleus would improve efficacy. Organelles and
molecules have always been drug targets, but until recently we have
not had the tools or capability to design and develop such highly
specific therapeutics. Organelle targeting has far-reaching
implications. For example, mitochondria are central to both energy
production and intrinsic apoptosis. Effectively targeting and
manipulating mitochondria has therapeutic applications for diseases
such as myopathies, cancer, neurodegeneration, progerias, diabetes,
and the natural aging process. The SARS-CoV-2 vaccines that exploit
the endoplasmic reticulum (for mRNA vaccines) and the nucleic
translational process (DNA vaccines) attest to the need for
organelle and molecular therapeutics. This book covers the status,
demand, and future of organelle- and molecularly targeted
therapeutics that are critical to the advancement of modern
medicine. Organelle and molecular targeting is the drug design and
drug delivery approach of today and the future; understanding this
approach is essential for students, scientists, and clinicians
contributing to modern medicine.
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