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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Mesenchymal Stem Cell Therapy (Paperback, 2013 ed.)
Loot Price: R5,520
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Mesenchymal Stem Cell Therapy (Paperback, 2013 ed.)
Series: Stem Cell Biology and Regenerative Medicine
Expected to ship within 10 - 15 working days
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Over the past decade, significant efforts have been made to develop
stem cell-based therapies for difficult to treat diseases.
Multipotent mesenchymal stromal cells, also referred to as
mesenchymal stem cells (MSCs), appear to hold great promise in
regards to a regenerative cell-based therapy for the treatment of
these diseases. Currently, more than 200 clinical trials are
underway worldwide exploring the use of MSCs for the treatment of a
wide range of disorders including bone, cartilage and tendon
damage, myocardial infarction, graft-versus-host disease, Crohn's
disease, diabetes, multiple sclerosis, critical limb ischemia and
many others. MSCs were first identified by Friendenstein and
colleagues as an adherent stromal cell population within the bone
marrow with the ability to form clonogenic colonies in vitro. In
regards to the basic biology associated with MSCs, there has been
tremendous progress towards understanding this cell population's
phenotype and function from a range of tissue sources. Despite
enormous progress and an overall increased understanding of MSCs at
the molecular and cellular level, several critical questions remain
to be answered in regards to the use of these cells in therapeutic
applications. Clinically, both autologous and allogenic approaches
for the transplantation of MSCs are being explored. Several of the
processing steps needed for the clinical application of MSCs,
including isolation from various tissues, scalable in vitro
expansion, cell banking, dose preparation, quality control
parameters, delivery methods and numerous others are being
extensively studied. Despite a significant number of ongoing
clinical trials, none of the current therapeutic approaches have,
at this point, become a standard of care treatment. Although
exceptionally promising, the clinical translation of MSC-based
therapies is still a work in progress. The extensive number of
ongoing clinical trials is expected to provide a clearer path
forward for the realization and implementation of MSCs in
regenerative medicine. Towards this end, reviews of current
clinical trial results and discussions of relevant topics
association with the clinical application of MSCs are compiled in
this book from some of the leading researchers in this exciting and
rapidly advancing field. Although not absolutely all-inclusive, we
hope the chapters within this book can promote and enable a better
understanding of the translation of MSCs from bench-to-bedside and
inspire researchers to further explore this promising and quickly
evolving field.
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