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Cancer Stem Cells - Philosophy and Therapies (Hardcover)
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Cancer Stem Cells - Philosophy and Therapies (Hardcover)
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An innovative theory proposes a new therapeutic strategy to break
the stalemate in the war on cancer. It is called cancer stem cell
(CSC) theory, and Lucie Laplane offers a comprehensive analysis,
based on an original interdisciplinary approach that combines
biology, biomedical history, and philosophy. Rather than treat
cancer by aggressively trying to eliminate all cancerous cells-with
harmful side effects for patients-CSC theory suggests the
possibility of targeting the CSCs, a small fraction of cells that
lie at the root of cancers. CSCs are cancer cells that also have
the defining properties of stem cells-the abilities to self-renew
and to differentiate. According to this theory, only CSCs and no
other cancer cells can induce tumor formation. To date, researchers
have not agreed on the defining feature of CSCs-their stemness.
Drawing from a philosophical perspective, Laplane shows that there
are four possible ways to understand this property: stemness can be
categorical (an intrinsic property of stem cells), dispositional
(an intrinsic property whose expression depends on external
stimuli), relational (an extrinsic property determined by a cell's
relationship with the microenvironment), or systemic (an extrinsic
property controlled at the system level). Our ability to cure
cancers may well depend upon determining how these definitions
apply to different types of cancers.
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