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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants - New Vistas In Parkinson's Disease Therapy (Hardcover, 2012)
Loot Price: R4,573
Discovery Miles 45 730
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Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants - New Vistas In Parkinson's Disease Therapy (Hardcover, 2012)
Series: Current Topics in Neurotoxicity, 1
Expected to ship within 10 - 15 working days
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The specific topic, "Isoquinolines And Beta-Carbolines As
Neurotoxins And Neuroprotectants - New Perspectives In Parkinson`S
Disease Therapy," was chosen in light of accumulating
neurobiological evidence indicating that, in addition to exogenous
neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
[MPTP]), endogenous compounds may play an important role in the
most common neurodegenerative disorders (e.g., Parkinson`s
disease). Two groups of amine related compounds, which appeared
chemically like MPTP, were detected in human brain and
cerebrospinal fluid (CSF): ss-carbolines (BCs) and
tetrahydroisoquinolines (TIQs). These are heterocyclic compounds
formed endogenously from phenylalanine/tyrosine (TIQs) and
tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively
and exert a wide spectrum of psychopharmacological and behavioral
effects. The TIQs and BCs may bind to their own high affinity sites
on neuronal membranes associated with or located close to the
receptors of neurotransmitters. Research on TIQs and BCs is
stimulated also by their possible role in pathological conditions,
especially parkinsonism and alcoholism. Recently, clinical interest
has been spurred by their role as neuroprotective, and even
neurorestorative, anticonvulsant and antiaddictive, substances. In
this book we are going to summarize, for the first time, the
results from behavioral, neurochemical and molecular experiments,
which demonstrate a wide spectrum of TIQs and BCs effects - from
their rather mild neurotoxic actions to the important
neuroprotective and antiaddictive properties. Additionally, the
recent results of experimental studies in vivo have allowed a much
better understanding and simultaneous comparison of the
neurochemical and molecular mechanisms underlying the
neuroprotective and neurotoxic actions of endogenous TIQs and BCs
and have pointed to the possibility of their therapeutic
applications in neurodegenerative diseases such as Parkinson's
disease.
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