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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 9: Human Diseases and Autophagosome (Hardcover)
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 9: Human Diseases and Autophagosome (Hardcover)
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity,
Infection, and Aging: Volume 9: Human Diseases and Autophagosome
offers a valuable guide to both cellular processes while helping
researchers explore their potentially important connections. Volume
9 emphasizes the role of autophagy in diseases, such as leukemia,
antifungal and antibacterial immunity, and transplantation. This
volume also explains, in detail, the molecular mechanism(s)
underlying the formation of autophagosomes, including the
progression of omegasomes to autophagosomes. This information is
important because one of the major functions of autophagy is to
degrade and eliminate excessive, old, and harmful materials from
the cell. Autophagosomes receive these materials (cellular cargo)
and transport them to lysosomes for degradation. Lysosomes contain
the digestive enzymes (hydrolases) that breakdown proteins, lipids,
carbohydrates, etc. (self-digestion). To further explain this
phenomenon, the role of the endoplasmic reticulum (ER) in the
formation of autophagosomes is discussed. ULK1 and Beclin 1
proteins are also important in the initial formation of
autophagosomes, and are also discussed. Because much of the early
research in this area was carried out using yeast cells, the role
of Golgi complex in the autophagosome formation in these cells is
explained. This volume also includes an explanation of the role of
the autophagy-related gene ATG5 in cancer (e.g., gastrointestinal
cancer). Paradoxically, autophagy is a "double-edged sword" because
it eliminates some pathogens, whereas it can be used by some
intracellular pathogens to multiply and cause infection. This book
is an asset to newcomers, providing a concise overview of the role
of autophagy in necrosis and inflammation, while also serving as an
excellent reference for more experienced scientists and clinicians.
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