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Current Topics in Microbiology and Immunology - Volume 102 (Paperback, Softcover reprint of the original 1st ed. 1983)
Loot Price: R2,922
Discovery Miles 29 220
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Current Topics in Microbiology and Immunology - Volume 102 (Paperback, Softcover reprint of the original 1st ed. 1983)
Series: Current Topics in Microbiology and Immunology, 102
Expected to ship within 10 - 15 working days
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Binding of various ligands (hormones, neurotransmitters,
immunological stimuli) to membrane receptors induces the following
changes: 1. Receptor redistribution (clustering, "capping") 2.
Conformational changes that can be detected by fluorescent probes
3. Alteration in membrane fluidity (spin label and fluorescence
polarization probes) 4. Changes in fluxes of ions and metabolites
5. Increased phospholipid turnover (especially of phosphatidyl
inositol) 6. Activation of membrane-bound enzymes (adenyl cyclase,
ATPase, transmethylases). Some of the early changes resulting from
or associated with the binding (adsorption) of virions to the host
cell membrane are of the same type. Adsorption of animal viruses to
cells is the ftrst step in a chain of events resulting in the
production of progeny virus on the one hand and in damage to cells
and tissues on the other. In the classical studies of viral
infection, cells are adsorbed with virus, usually for 60 min, and
the changes induced by the virus in the host cell are recorded
thereafter. In the past decade, more and more studies have been
aimed at the events occurring in these ftrst 60 min of the
so-called adsorption period. These studies deal with the nature of
adsorption, e. g. , the ligand-receptor type of interaction between
the virus and the cell membrane. Many receptors for viruses were
identifted and so were the viral proteins which take part in
adsorption.
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