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Major Histocompatibility Complex - Evolution, Structure, and Function (Paperback, Softcover reprint of the original 1st ed. 2000)
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Major Histocompatibility Complex - Evolution, Structure, and Function (Paperback, Softcover reprint of the original 1st ed. 2000)
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Every biological system is the outcome of evolution and has a
history all its own. This history dictates how the system works and
why it has certain properties and not others. This is why we need
to study not only the structure and function, but also the history
of the system. This argument undoubtedly applies to the study of
the immune system and also to the study of the major
histocompatibility complex (MHC). Since 1989, researchers of
various scientific disciplines who share a deep inter est in MHC
evolution have held a meeting every two years to discuss their
latest research developments, exchange ideas, and foster
friendship. Together with my colleagues Drs. Naoyuki Takahata and
Yoko Satta, I organized the Sixth Interna tional Workshop on MHC
Evolution in Hayama, Japan, May 25-29, 1999. This volume is the
proceedings of that conference. It covers diverse topics pertinent
to MHC evolution, including the origin of the adaptive immune
system, the organi zation of the MHC in humans and other model
vertebrates, MHC-parasite co evolution, and the nature and origin
of MHC polymorphism. I hope that this book will be of interest not
only for MHC researchers and immunologists, but also for other
specialists who are interested in the evolution of biological
systems in gen eral.
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