Since the initial establishment of Robert Koch's postulates in
the nineteenth century, microbial protein toxins have been
recognized as a major factor of bacterial and fungal virulence. An
increasing number of proteins produced and secreted by various
bacteria, yeasts and plants are extremely toxic and most of them
developed remarkably "intelligent" strategies to enter, to
penetrate and to finally kill a eukaryotic target cell by modifying
or blocking essential cellular components.
This book describes the strategies employed by protein toxins to
render their pro- and eukaryotic producers a selective growth
advantage over competitors. In providing an up-to-date overview on
the mode of protein toxin actions, it accommodates biomedically and
biologically relevant toxin model systems. As a result, it
significantly broadens our perspective on biochemical architecture
and molecular ploy behind the lethal principles of pro- and
eukaryotic toxins.
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